ABC of Clinical Haematology (ABC Series) by Drew Provan

By Drew Provan

This moment variation of the ABC of medical Haematology is a complete and useful advisor to this vast ranging speciality, protecting the haematological facets of such parts as pathology, molecular technological know-how, melanoma, and normal medication. it is a brief quantity together with chapters on all components of haematology written through those that take care of those illnesses every day. The ebook offers descriptions of those ailments and describes the pathways excited by analysis and therapy. complete color is used all through this seriously illustrated e-book, utilizing medical fabric and textual content packing containers to emphasize key issues. we have now additionally attempted to maintain jargon to a minimal in order that the textual content doesn't require huge previous wisdom.

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Sample text

1 Formation of the Philadelphia chromosome resulting in a bcr–abl fusion gene that generates a fusion protein (p210) responsible for the chronic myeloid leukaemia (CML) phenotype. 2 Mechanism of action of imatinib. leukaemia cells by blocking the enzymatic function of the Bcr–Abl oncoprotein and thereby permits regeneration of normal haemopoietic cells (Fig. 2). 1). Often the disease is detected as a result of routine blood tests performed for unrelated reasons, and up to 50% of patients are totally asymptomatic at the time of diagnosis.

It is important to assess whether patients have a significant chance of benefit from intensive chemotherapy. 1). Such decisions are clearly complex and must be taken in careful consultation with the patients and their families. 1 Predicted outcome in patients with acute leukaemia according to age and subtype Type Survival at 5 years Childhood ALL Adult ALL Childhood AML AML (< 55 years) AML (> 55 years) AML > 55 years with poor risk karyotype APL 70–80% 30–40% 60% 40% 15% <5% 80% ALL, acute lymphoblastic leukaemia; AML, acute myeloid leukaemia; APL, acute promyelocytic leukaemia.

4). The clinician should explain the propensity of the disease to progress to an advanced phase. 5 Course of chronic myeloid leukaemia, showing progression to blastic phase. practice most patients are advised to start treatment with imatinib mesylate (Glivec ®; Novartis) or an imatinib-containing combination. Younger men should be offered cryopreservation of semen if necessary. If CML is diagnosed in pregnancy, the woman should have the chance to continue to term. CML has no adverse effect on pregnancy and pregnancy has no adverse effect on CML.

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