Alkaline Phosphatase by Robert B. McComb

By Robert B. McComb

There may be without doubt that alkaline phosphatase is among the so much broadly in­ vestigated of all enzymes. This has resulted from the ubiquity of its distribution, and from the benefit and sensitivity with which its job could be measured. regrettably, those wide-ranging yet frequently superficial experimental stories were up through extensive and systematic investigations in just a couple of constrained components of the biochemistry and chemical pathology of alkaline phosphatase. the end result has been the buildup of a systematic literature of intimidating proportions, and the inevitable rediscovery of already­ recognized proof in regards to the enzyme. Scientists are taught early of their careers that, within the phrases of Sir John Herschel, "Hasty generalization is the bane of technological know-how. " however, moments arrive in all spheres of medical job whilst generalization turns into crucial, to codify and to choose from the mass of information already collected, and to supply beginning issues for brand spanking new advancements and new traces of research. this is often very true in a box reminiscent of alkaline phosphatase study, within which very actual risks exist that the seeds of basic figuring out may be misplaced amidst an unexamined harvest of empirical observations. The historical past of the learn of alkaline phosphatase offers a number of cases while invaluable generalizations have emerged. sometimes, the conclusions drawn at the foundation of accessible facts have been flawed; extra usually, they've got stood the try out of extra experimentation, and constantly, they've got supplied new insights into the character and correct­ ties of this enzyme.

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Coli ,54 have defective cell walls. These organisms release alkaline phosphatase into the culture medium during growth. In some instances, as in Bacteroides rnminicola, the enzyme is fIrmly bound to the cell-wall structures and cannot be released except by complete disruption of the cells. S5 Inouye et al. 56 synthesized E. coli alkaline phosphatase in a cell-free system, using DNA or messenger RNA templates. 2. Electron-microscopic appearance of a single Escherichia coli organism stained for alkaline phosphatase.

Clin. , 9,226,1939. 176. Gutman, A. , and Hanger, F. , Differential diagnosis of jaundice by combined serum phosphatase determinations and cephalin flocculation test, Med. Clin. , 25,837, 1941. 177. McLagan, N. , Laboratory tests in the diagnosis of liver disease: A report on three procedures, Br. Med. , 2,363,1944. 178. , Chen, Y. , and Ivy, A. , On the cause of the elevation of serum phosphatase in jaundice,!. Bioi. , 127, 79, 1938. HISTORICAL BACKGROUND 23 179. Carr, J. , and Foote, F. , Alkaline and acid phosphatase levels in the serum of dogs after ligation of the common bile duct,Arch.

4,497, 1908. 21. , and Young, W. , The alcoholic ferment of yeast juice. III. The function of phosphates in the fermentation of glucose by yeast juice, Proc. R. Soc. London Ser. B, 80, 299, 1908. 22. Levene, P. , On nucleases, J. Bioi. , 9, 399, 1911. 23. , Uber das Vorkommen einer Glycerophosphotase in tierischen Organen, Biochem. , 39,1,1912. 24. , Verhalten der Kohlenhydratphosphosiiure Ester im Tierk6rper, Z. Physiol. , 79, 375, 1912. 25. Schmidt, R, Weitere Untersuchungen tiber Fermente in Darminhalt (Meconium) und Mageninhalt menschiicher Foeten und Neugeborener, Biochem.

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