Animal Hematotoxicology: A Practical Guide for Toxicologists by G.O. Evans

By G.O. Evans

Hematology information from in vivo toxicology reports is still certainly one of  the main predictive measures for human danger, because the similar measurements made in pre-clinical toxicology reports will be made in early scientific trials.

Covering the 3 major blood mobilephone kinds – erythrocytes, leukocytes and thrombocytes, this paintings is designed to elucidate themes for brand new entrants to the fields of laboratory animal hematology and toxicology, specially these issues the place the principles for human hematology don't constantly observe. a whole bankruptcy is dedicated to immunotoxicology, a systematic self-discipline that's heavily aligned with hematology.

The textual content additionally addresses pre-analytical and analytical variables that have an effect on animal reports, as those play a much more vital half whilst analyzing facts not like people the place lots of those variables may be good managed or have much less physiological impact. info has been collated from released papers, textbooks and unpublished information: Readers are supplied with key references to inspire extra learn

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See Chapter 5. Microcytic Anemia In microcytic anemia, the mean cell volume and hemoglobin are reduced. Usually these effects are due to alterations of heme synthesis that slow maturation processes. Iron deficiency anemia is sometimes classified as a maturation defect, but in this discussion it will be treated as a heme production-related anemia. Decreased Production Xenobiotics may affect hemoglobin production by toxic effects on the marrow cells, reducing heme synthesis, altering the rate of erythropoiesis via hormones or reduced renal EPO production.

Weiss, D. J. 2004. Evalution of canine bone marrow proliferative disorders by use of flow cytometry analysis of CD45 expression and intracytoplasmic complexity. Comp. Clin. Pathol. 13:51–58. In Vitro Assays Brott, D. , Maher, R. , Parrish, C. , Richardson, R. , and Smith, A. K. 2003. Flow cytometric characterization of perfused bone marrow cultures: Identification of the major cell lineages and correlation with the CFU-GM assay. Cytometry 53A:22–27. Caro, J. 1991. Clonal assays for hemopoietic progenitor cells.

1994; Pauluhn, 2004, 2005). , 1962; Azen and Schilling, 1964; Bates and Winterbourn, 1984). The large number of oxidants producing methemoglobinemia include aminophenols and their derivatives, some antimalarials, chlorates, nitrites, hydroxylamines, sulfonamides, and aromatic compounds with amino nitro or hydroxyl groups. The increased production of methemoglobin and sulfhemoglobin is often associated with Heinz body formation. Methemoglobin Methemoglobin is also known as ferrihemoglobin due to the presence of ferric rather than ferrous heme iron.

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