By Beverly A. Teicher
Beverly Teicher and a panel of exotic investigators survey the state of the art of antiangiogenesis study from the lab bench to scientific trials. well timed and authoritative, the individuals summarize our present knowing of tumor progress and its dependence on vascular improvement, in addition to the current prestige of antiangiogenic brokers in preclinical and medical improvement. additionally, the booklet additionally examines what's recognized in regards to the mechanisms in which those healing brokers intervene with tumor vasculature and grapples with the matter of building standards through which to evaluate their scientific efficacy. Antiangiogenic brokers in melanoma treatment deals a distinct state-of-the-art compendium of antiangiogenic study, taking inventory of what has been entire , the place the experimental therapeutics of antiangiogenic brokers goes, and the continued evolution in their function in melanoma therapy and novel drug improvement.
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Additional info for Antiangiogenic Agents in Cancer Therapy (Cancer Drug Discovery and Development)
Radiat. Oncol. Biol. Phys. 19, 953–961. 45. Horsman, M. , Hansen, P. , and Overgaard, J. (1989) Radiosensitization by nicotinamide in tumors and normal tissues: the importance of tissue oxygenation status. Int. J. Radiat. Oncol. Biol. Phys. 16, 1273–1276. 46. Simon, J. , and Guichard, M. (1993) Nicotinamide and carbogen: major effect on the radiosensitivity of EMT6 and HRT18 tumors. Radiother. Oncol. 28, 203–207. 47. Thomas, C. , and Guichard, M. (1995) Tumour oxygenation, radiosensitivity and necrosis before and/or after nicotinamide, carbogen and perflubron emulsion administration.
The most important disadvantage of any technique that correlates tissue oxygenation and vascular density is that the measurements are indirectly related (9,13,19). With cryospectrophotometry techniques, the oxygen present in hemoglobin in microvessels is assessed on frozen tissue sections (13). Bioluminescent imaging of metabolites within tumor cells can be performed on microscopic frozen sections of biopsy and can show the distribution of metabolites in tumors, giving only indirect information about the oxygenation status.
Kelleher, D. ), Gustav Fischer Verlag, Stuttgart, pp. 219–232. Chapter 2 / Oxygenation of Solid Tumors 35 57. , Knapstein, P. , and Vaupel, P. (1993) Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix. Radiother. Oncol. 26, 45–50. 58. , and Knapstein, P. G. (1993) Tumor oxygenation: a new predictive parameter in locally advanced cancer of the uterine cervix. Gyn. Oncol. 51, 141–149. 59. Wong, R. K. , and Hill, R. P. (1997) Heterogeneity of polarographic oxygen tension measurements in cervix cancer: an evaluation of within and between tumor variability, probe position and track depth.