By Wojciech Gorczyca
This huge reference overlaying neoplastic hematopathology comprises over 500 color illustrations depicting hematopoietic tumors regarding lymph nodes, spleen, bone marrow, and usually affected extranodal organs, with detailed emphasis at the differential prognosis. It discusses uncomplicated scientific, prognostic, morphologic and phenotypic information, with various tables summarizing the phenotypic profiles of the most typical hematologic tumors. a massive characteristic of this e-book is an method of hematologic tumors in line with the WHO type, with appropriate examples and emphasis at the most precious morphologic and immunophenotypic beneficial properties utilized in diagnosis.It may be a useful reference for all training hematologists, oncologists and pathologists.
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Additional resources for An Atlas of Differential Diagnosis in Neoplastic Hematopathology
The rare non-neoplastic B-cells (upper left quadrant) are CD19+/CD5− and residual T-cells (lower right quadrant) are CD19−/CD5+. Aberrant expression of CD5 by B-cells is typical for B-CLL/SLL and mantle cell lymphoma. 11F illustrates moderate expression of CD10 by CD19+ B-cells (upper right quadrant). 12 presents the difference between polytypic and monoclonal expression of surface light-chain immunoglobulins. 12A) shows two distinct populations of cells, based on the expression of CD20 (B and C; x-axis): CD20+ cells (B-cells) and CD20- cells (T-cells).
Expression of CD11b and CD11c is most typical for acute monocytic leukemia, where the expression tends to be bright or at least moderate. Other AMLs often have moderate CD11c, but CD11b is usually negative. Expression of pan-myeloid antigens (CD13, CD33) can be seen occasionally in precursor B- or T-lymphoblastic leukemias. Acute monocytic leukemia and acute megakaryoblastic leukemia show usually dim CD13 and bright CD33. The latter shows dim CD117 and negative CD34, which creates a characteristic FC pattern, prompting the addition of CD41 and CD61 during flow analysis.
11C) display bright expression of CD11c and CD3, respectively. 11D shows B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL; green) with dim expression of CD20 (x-axis) and positive expression of lambda immunoglobulins (y-axis). As illustrated, FC gives information about the presence or absence of a given antigen as well as its intensity of expression. Dim expression of CD20 and surface light-chain immunoglobulin is characteristically seen in B-chronic lymphocytic leukemia/ small lymphocytic lymphoma.